Essay Topics For Behavior - What is Most Important To You?

<h1>Essay Topics For Behavior - What is Most Important To You?</h1><p>When I was an understudy, I got my work done on exposition themes for conduct. It was an overwhelming undertaking. That is, on the off chance that you've never accomplished any work on exposition themes for conduct, you likely invested the whole energy in your mind attempting to make sense of what to expound on in your essay.</p><p></p><p>The truth is, article subjects for conduct don't need to be troublesome. The inquiry is, what would it be a good idea for you to expound on? What is the conduct that you might want to address in your exposition? The more you invest energy contemplating what is critical to you, the better you will be at discovering article themes for behavior.</p><p></p><p>There are many exposition subjects for conduct. One of them is child rearing. At the point when you are a parent, you are in all probability confronted with numero us difficulties. Here and there you are the parent, and once in a while you are the parent's youngster. Frequently however, you are both.</p><p></p><p>Parents, when all is said in done, have a duty to be available at the hours of numerous contentions, regardless of whether they are school related or guardians battling about cash. Here and there guardians need to manage parent-youngster clashes, when a parent requests that the kid quit utilizing some conduct since it is illicit. I know a few guardians who venture to such an extreme as to bring the kid into defensive custody.</p><p></p><p>There are numerous issues that guardians need to manage while child rearing their kids. Child rearing additionally includes their absence of control and their powerlessness to advise the kids how to behave.</p><p></p><p>Therefore, while doing your exposition, invest some energy pondering the issues that guardians are proceeding w ith their kids. At the point when you think of some powerful paper subjects for conduct, it will make your papers more effective.</p><p></p><p>There are other article themes for conduct that you should investigate. The significant thing is to make sense of what subjects are the most critical to you. When you have made sense of that, it will be simpler to discover paper points for behavior.</p>

What Needs to be Done About Research Paper Writing Service

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The Occult Research Paper Topic How It Affects The Art And Arts Of Today|endoftext|

The Occult Research Paper Topic: How It Affects The Art And Arts Of Today|endoftext|When occult research papers are written, most authors do so in an effort to research the history of magic and religion. They wish to examine the ways that magic has influenced the arts, and how it has influenced both societies and the lives of men. There are also other reasons for writing these papers. In fact, there are even some people who go into occult research without any intention of writing an article, but just to learn a little more about the subject.The most common occult research paper topics are those involving religious influences. Most publications of this type are centered around Christianity and their influence on the world. In this day and age, Christianity and mysticism can't be separated. People throughout the world simply don't have any use for the occult, and most don't even realize that it exists. When people come across articles regarding magic, they tend to be confused, or have no idea what is being discussed.The simplest way to understand this connection between Christianity and the occult is to look at the fact that for centuries, many books and plays dealt with the topic of how Christianity influenced magic. Many of the plays, which are the most popular forms of entertainment at the moment, have a definite Christian focus. These are the type of play that are read by most people, and they have been popular since the dawn of Christianity. In fact, there are certain types of plays that deal with magic which date back to the first millennium BC. Even in the modern age, it seems as though magic still has a lot of influence on society.Another part of the reason for writing occult research paper topics is to investigate how occult rituals are performed. This is something that people often overlook. Even with many religions out there, there are still questions about what are going on behind closed doors. A good example of this is how the real importance of Sata nism in Western society is being questioned.History shows that a lot of people really hate the idea of Satanism. However, you shouldn't be surprised at all when you find some small rural communities which contain large numbers of members of the occult. A lot of people will shy away from discussing magic with outsiders, but there are some writers who will approach these areas with no fear at all. Such people are those who have studied enough about magic and the occult to understand what is being said. There are also some people who have studied the subject matter so much that they even have created their own articles. These articles are more focused on information about the occult, and so there is less focus on real discussions of magic.Some occultists are fine with either kind of writing, but others prefer the spiritualist works. To many people, it seems like there is a clear divide between the two. This is actually not the case, though. As long as the person writing the article is willing to research and write about the topic, then they will find a niche that is appropriate for them.There are many different words that refer to magic, and in this day and age, there are several people who are trying to describe the actual term. While there is a clear divide between the two, the distinctions are also very important. There are plenty of writers out there who prefer to stick to the spiritualist terms, and there are those who are open to discussing them.Some occult researchers even try to look at some of the events that happened during the witch hunts, which was one of the biggest problems for the occult. If the writer has enough knowledge, they can take a few of these incidents and make them into interesting research topics. It would be better if they could turn these into real articles. That way, it would have more weight and impact.

The Potential Treatment of Alzheimers Disease Through CRISPR-Cas9 Genome Editing - Free Essay Example

Named after Dr. Alois Alzheimer who discovered the disease in 1906, Alzheimers disease is the progressive deterioration of the brain that slowly destroys cognitive function. While some treatments exist to alleviate the symptoms of Alzheimers disease, there is no cure. Considering that researchers have studied the disease for over 100 years, making steps toward finding a cure is urgent. With evidence for the potential risk and protective factors of Alzheimers disease, dementia, and cognitive decline, researchers are now looking at gene editing as a solution. The CRISPR-Cas9 system, is an inexpensive, yet powerful, tool used by researchers to alter DNA sequences and gene function that has already shown promise in other neurological disorders. Through gene editing, the CRISPR-Cas9 system would go beyond the temporary lessening of Alzheimers diseases symptoms and potentially prevent or stop the depreciation of the brain by targeting associated genes and correcting genetic defects. When examining the applications of CRISPR-Cas9, however, it is important to factor in both the ethical concerns of using this biotechnology, including the extent to which CRISPR should be permitted and who should have access to this technology, and concerns of not using it. While the system presents many ethical concerns and lingering questions, CRISPR-Cas9 provides a revolutionary and much-needed potential solution to Alzheimers disease. In researching potential treatments for Alzheimers disease, it is necessary to examine both types: early onset and late onset.1 Early-onset Alzheimers disease, also called familial Alzheimers disease (FAD), occurs in people between the ages of 30 and 60 and represents less than 10% of all cases. FAD has a strong genetic component caused by mutations on chromosomes 1, 14, and 21.6 Mutations on chromosome 1 lead to the formation of amyloid precursor protein (APP), and those on 14 and 21 lead to the formation of abnormal presenilin 1 (PSEN1) and abnormal presenilin 2 (PSEN2) respectively. Late onset Alzheimers disease occurs in patients over the age of 60 and represents over 90% of all Alzheimers cases. In addition to genetic factors, lifestyle and environmental factors such heart and metabolic conditions also contribute to this type of Alzheimers disease. The apolipoprotein E (APOE) gene, particularly the APOE e4 allele is associated with increased risk of developing Alzheimers. Theref ore, in order to cure Alzheimers disease, these genes should be targeted specifically, yet there is no guarantee this will be a solution given the impact of environmental factors. Plaques and tangles are the two neurobiological markers of Alzheimers disease as opposed to dementia. Plaques are clumps of amyloid beta protein, which is derived from APP cleaved by beta secretase and gamma secretase, that breakdown brain cells by disrupting cell communication. Brain cells use an internal support and transport system that transports essential nutrients and materials. This system requires the normal structuring and function of a protein, tau. In Alzheimers Disorder, tau protein threads tangle abnormally inside brain cells, damage the transport system, and contribute to the death of brain cells. The problem, however, is that the presence of plaques and tangles, to confirm Alzheimers disease, can only be observed in an autopsy after death. Despite this, the accumulation of the Amyloid Beta protein can now be seen in PET scans as early as 15-20 years before symptoms are present, leaving a large potential therapeutic window.4 In order to properly treat the neurobiologica l markers of Alzheimers, and take advantage of preventative and disease reversal treatment, the ability to diagnose plaques and tangles is essential. Symptomatic treatment drugs are divided into two main categories: cholinesterase inhibitors and NMADA receptor antagonists. The first mechanism is used in classical drugs called cholinesterase inhibitors, prescribed for mild to moderate cases, that attempt to slow down the Alzheimers disease by inhibiting the enzyme that breaks down acetylcholine. Donepezil, galantamine, and rivastigmine are three cholinesterase inhibitors.8 The drug Memantine is a NMDA (N-methyl-D-asparte) receptor antagonist and is used for moderate to severe cases. Memantine protects brain cells against excess glutamate, a chemical messenger released by damaged Alzheimers cells that usually attaches to NMDA receptors and results in a cell-damaging over-exposure of calcium. Despite much research and efforts, there remain no options for the prevention and treatment of Alzheimers disease. There are currently three common gene editing tools available, including Zinc Finger Nucleases (ZFNs), transcription activator-like effectors nucleases (TALENs), and the clustered regularly interspaced short palindromic repeats (CRISPR). In particular, CRISPR-associated nuclease 9 (CRISPR/Cas9) is the most attractive option because it is faster, cheaper, more accurate, and more efficient than any other existing methods. CRISPR technology is adapted from naturally occurring defense mechanisms of bacteria and archaea. Organisms use CRISPR derived RNA and Cas proteins like Cas9 to stop the attacks of invader viruses by chopping up their DNA. These components are then transferred into another organism to perform gene editing by cutting DNA and tricking a cells natural DNA repair mechanisms to complete a desired change. In particular, Cas9 is directed to cut a region of DNA, fusing crRNA, that is specific to the DNA target, and tracRNA to create a single guide RNA that consists of a small pre-designed RNA sequence. The cells natural repair mechanisms introduce changes in the genome and repair the Cas9 induced double strand breaks. Insertions and deletions (INDELS) may be introduced to disrupt gene function. Science is now turning towards using CRISPR-Cas9 for Alzheimers disease after successful trials for Huntingtons disease, a different neurological disorder. Researchers were able to successfully edit out the faulty region of the mutant HTT gene in an in vivo mice model using cells derived from patient samples using the technique. There is clear potential for the use of CRISPR-Cas9 in correcting the autosomal-dominant mutations of PSEN1 and PSEN2 in early-onset Alzheimers disease models. This is supported by the fact that CRISPR-Cas9 was recently used to correct the PSEN2 autosomal mutations in iPSC-derived neurons. In addition, CRISPR/Cas-9 was used to knock out the Swedish APP mutation in patients. There is also evidence that CRISPR/Cas9 is a useful technology in treating late-onset Alzheimers. A recent, although not formally published study, shows proof that CRISP/Cas9 can be used to control the amyloid pathway attenuating cleavage and A production, while up-regulating the neuroprotective a- cleavage. This APP editing, by targeting the C-terminus region, was proven to be effective in various human neurons and mouse cells. Lastly, research shows that CRISP/Cas9 can be used to convert the APOe4 allele, which is associated with an increased risk of developing Alzheimers disease, to an APOe3 allele to lower this risk. Ethical and social issues regarding the use of CRISPR in people are centered around philosophical and safety dilemmas. The philosophical arguments question whether or not CRISPR should be used to alter germ-line cells, in human embryos, that would be passed on to the next generation. In addition, there is a fear that this technology will lead to the creation of designer babies. Recently in a 2015 Napa Valley meeting, a leading group of CRISPR-Cas9 developers, scientists, and ethicists met to discuss the ethical limits of CRISPR systems. Shortly after, a multidisciplinary committee of the National Academies of Sciences, Engineering, and Medicine published a report that favored somatic genome editing, but not for any kind of enhancement. In terms of safety, CRISPR is a relatively new technology and much of its effects continue to be unknown. Some are worried that the technology could still be more accurate and that unknown genetic changes could be occurring with unforeseen consequences . For example, it is important to ensure that the disruptions of the DNA occur in the mutant gene and not in the wild-type allele. While accuracy could be considered an issue, CRISPR technology is advances at such a rapid pace that technical limitations should be of minimal concern. The consequence of editing a gene in germline may be unclear and unpredictable because the interaction of genetic information and biological phenotypes is not clear, however. And, considering that Alzheimers has many environmental factors adds to this concern. Another moral and ethical consideration, however, is not engaging in genome editing considering the tremendous social and economic cost of Alzheimers. Alzheimers disease currently affects 5.5 million Americans and this number is expected to triple by 2050 due to a growing and aging population. In addition, it is the third leading cause of death among Americans only trailing heart disease and cancer. $259 billion are going towards managing Alzheimers in the United States today, and this cost is expected to reach $1.2 trillion in 2050 which would bankrupt the entire health care system. Therefore, Alzheimers disease not only affects a large portion of the population due to the large number of those diagnosed, but is an economic burden to everyone. As a result, some may consider not using CRISPR unethical because continuing without a solution is detrimental to everyones health. In addition to Alzheimers as a social challenge due to economic cost, the progression of symptoms presents a social challenge to both those diagnosed and those around them. Mild Alzheimers disease is characterized with symptoms such as wandering and getting lost, trouble managing expenses, repeating questions, taking a longer time to complete everyday tasks, and personality changes. Moderate Alzheimers disease damages areas of the brain that control language, reasoning, sensory processing, memory, and conscious thought, causes patients to have hallucinations, delusions, and paranoia, and makes them unable to recognize friends and family.1 Patients with severe Alzheimers cannot communicate with others and are completely dependent another person as their bodies completely shut down.1 These changes may frustrate the patient and be hard to comprehend for others. Tasks that were always handled by the diagnosed, will now have to be taken care of by someone else. The slow deterioration of b odily function can be difficult to watch especially when so much assistance is required, causes emotional pain, and tension from economic burden making any solution worth it. The CRISPR/Cas9 system has the ability to target just about any gene and can do so more efficiently and effectively than any other current gene-editing mechanism. In doing so, however, there needs to be both clear cut guidelines reflecting the ethical use of CRISPR/Cas9 as well assufficient research regarding a disease in order to ensure that gene-mutation has an effective outcome. In the case of Alzheimers disease, there needs to be an accurate method of diagnosis, considering that a significant number of diagnosis are mistaken as Alzheimers disease instead oftreatable conditions such as depression, vitamin deficiencies, and hypothyroidism.3 In addition, the particular genetic risks leading to both early and late onset Alzheimers disease need to be made clear.Regulations need to be put in place protecting the life-saving aspect of CRISPR, rather than its cosmetic potential, and should require deep reasoning especially when consideringgremlins gene editing. Despite risks, urgency mus t also take precedent. Whether CRISPR-Cas9 gene editing realizes itself as a therapeutic tool in treating Alzheimers is in the hands of researchers, this kind of treatment, with sufficient regulation, will prove revolutionary as these symptoms not only impair the person with the disease, but also disable the lives of their family and friends.